Accelerated epithelialization and improved wound healing metrics in porcine full‐thickness wounds transplanted with full‐thickness skin micrografts

Epithelialization in Wound Healing: A Comprehensive Review.

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types part...

Altering the size of skin micrografts affects the healing quality of cutaneous wounds

Wound re-epithelialization: modulating keratinocyte migration in wound healing.

An essential feature of a healed wound is the restoration of an intact epidermal barrier through wound epithelialization, also known as re-epithelialization. The directed migration of keratinocytes is critical to wound epithelialization and defects in this function are associated with the clinical phenotype of chronic non-healing wounds. A complex balance of signaling factors and surface protei...

Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing

The commercial use of epidermal growth factor (EGF) is extensive and has been shown to be effective for skin wound healing in clinical practice. There is evidence to indicate that the topical administration of EGF significantly accelerates re-epithelialization by promoting keratinocyte mitogenesis and migration following acute injury; however, the mechanisms involved remain to be elucidated. Th...

Experimental reconstruction of teat cutaneous wound by ear skin graft in dairy cattle

BACKGROUND: Teat lacerations are serious injuries thatendanger the survival of a cow within the herd. In excessivelacerations, the wound should be left to heal by second intentionhealing process. However, tissue contraction during healing canchange the alignment of the teat, creating problems for machinemilking. OBJECTIVES: The purpose of the present study was toevaluate the transplantation of ...